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Chemotherapy day 32 - another good day

6 more chemo tablets today plus 4 steroid and 3 anti nausea as prescribed. I will also be taking the vitamin B6 tablet as well. 

Another good day with practically no tingling. But another night of poor sleep.

A conversation with Jo about Vitamin B6, pyridoxine and she advised that I should probably take this for a year after the Chemotherapy has been completed. The effects of the Capox are likely to continue for at this that long. The US National Library of Medicine, National Institutes of Health website page states

Long-Term Retention of Oxaliplatin Derivatives

Given that the 3rd half-life of oxaliplatin is in the order of hundreds of hours, accumulation of the drug in tissues may presumably be expected. In this regard, a study examined long-term retention of platinum 8–75 months after treatment with cisplatin and oxaliplatin .

The results showed that the plasma concentration of platinum in individuals previously exposed to oxaliplatin or cisplatin is larger by a factor of 30 than that in unexposed controls. The metal is found in both whole and ultrafilterable plasma. Risk factors for persistent high levels are decreased glomerular function and high cumulative dose. The authors demonstrated that the platinum found is still reactive, capable of forming platinum–dna adducts in vitro. Although the physiologic significance of this reactivity is unknown, the findings are of concern with regard to long-term toxic effects such as secondary malignancies.


Lancet Oncology article, 3 versus 6 months of adjuvant oxaliplatin-fluoropyrimidine combination therapy for colorectal cancer (SCOT): an international, randomised, phase 3, non-inferiority trial  gives insight to to the duration of side effect with the highest levels being experienced during the 1st and 2nd cycle. 

Pulse rate 66 bpm this morning.

BSC - 3

A good day!






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